MOTS-c Research
Mitochondria-Derived Peptide
Research area: metabolic signaling
MOTS-c is a 16-amino acid peptide encoded within the mitochondrial genome (12S rRNA gene). It is one of a class of mitochondria-derived peptides (MDPs) recognized for its signaling roles that extend well beyond the mitochondria, traveling to the cytosol, plasma, and nucleus.
Research Areas
AMPK Metabolic Signaling
Research focuses on MOTS-c's activation of AMPK signaling pathways involved in glucose uptake, lipid metabolism, and overall metabolic regulation in skeletal muscle tissue and other organs.
Insulin Sensitivity Research
Preclinical studies have investigated MOTS-c's potential influence on insulin receptor signaling and glucose transporter (GLUT4) pathway activity in muscle and adipose tissue.
Mitochondrial-Nuclear Communication
Research explores how MOTS-c travels from mitochondria to the nucleus to regulate gene expression involved in nuclear AMPK signaling and metabolic stress response pathways — a novel form of retrograde mitochondrial signaling.
Aging & Longevity Research
Studies have noted that circulating MOTS-c levels decline with age and increase with exercise. Research investigates its relationship to age-related metabolic changes and longevity-associated signaling pathway research.
Mitochondria-derived peptide; metabolic signaling research. Investigational compound.
Research References
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